Why similar protein sequences encode similar three-dimensional structures?
نویسندگان
چکیده
منابع مشابه
Current computer modeling cannot explain why two highly similar sequences fold into different structures.
The remarkable recent creation of two proteins that fold into two completely different and stable structures, exhibit different functions, yet differ by only a few amino acids poses a conundrum to those hoping to understand how sequence encodes structure. Here, computer modeling uniquely allows the characterization of not only the native structure of each minimally different sequence but also s...
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ژورنال
عنوان ژورنال: Theoretical Chemistry Accounts
سال: 2009
ISSN: 1432-881X,1432-2234
DOI: 10.1007/s00214-009-0656-3